Star running back Christian McCaffrey is listed as questionable for the 49ers’ regular season opener on the road against the Seattle Seahawks. He did not participate in San Francisco’s Friday practice with a calf injury.
He was suited up for today’s practice but went through his own training routine apart from the other running backs.
McCaffrey told reporters after practice that he feels good and plans to play Sunday.
‘I feel great about where I’m at,’ McCaffrey said. ‘Just unfortunately, when you have the injury history that I have, sometimes when you don’t practice things get blown out of proportion. Like I said, I feel great.’
McCaffrey said he wanted to be cautious ahead of Week 1.
‘I felt like it was the smart thing to do to not finish the practice because I’ve been there before and I’ve been my own worst enemy in situations like that,’ he said.
McCaffrey missed the first eight games of the 2024 NFL season with calf and Achilles injuries. A year after winning Offensive Player of the Year, McCaffrey failed to score a touchdown in just four games of action.
The 29-year-old running back appeared to have a healthier offseason in 2025 but this is a setback with less than a week until the 49ers’ first game.
San Francisco traded for running back Brian Robinson Jr. two weeks ago from the Washington Commanders for a sixth-round draft pick. His addition looms larger with this news if McCaffrey is out for extended period or has a reduced snap count.
49ers RB depth chart
Robinson Jr. is one of multiple running backs who could shoulder a larger load of the offense if McCaffrey misses time. Here’s how the depth chart at the position looks ahead of the season opener:
Christian McCaffrey
Brian Robinson Jr.
Isaac Guerendo
Jordan James
The team also has Sincere McCormick signed to the practice squad.