It’s been another injury-filled campaign for the San Francisco 49ers in 2025.
A young defense with lots of rookies or first-time starters lost stars Nick Bosa and Fred Warner for the entire season in Week 3 and Week 6, respectively. All-Pro tight end George Kittle and wideout Ricky Pearsall have both missed significant time with injuries, as well.
Kittle and Pearsall aren’t the only major pieces on offense to miss time, though.
For the last month, fans have been wondering on a weekly basis if franchise quarterback Brock Purdy would start again after suffering a toe injury in Week 1 against the Seattle Seahawks. He returned to the lineup in Week 4 to take on the Jacksonville Jaguars but hasn’t played since.
That’s left former first-round pick Mac Jones to take over starting duties for much of the year. He’s gone 5-2 as a starter and has kept the 49ers in the crowded NFC West race.
Now at 6-3 entering Week 10, the 49ers welcome the division rival Los Angeles Rams to Levi’s Stadium for their second game of the regular season. Last time around in Week 5, Jones led the 49ers to a thrilling 26-23 overtime win on ‘Thursday Night Football.’
Will Purdy get a chance to make it 2-0 against the Rams this year? Here’s what we know about his status for Week 10.
Is Brock Purdy playing this week?
In a shift compared to the last month, Purdy could be available to play against the Rams. Jones will get the start but Purdy is listed as questionable, per multiple reports.
This is similar to last week’s starting quarterback situation against the New York Giants. San Francisco went with Jones as the starter but kept Purdy available to play if need be.
With Jones at the helm for most of the season, San Francisco ranks fifth in the league in passing yards and 10th in total yards entering Week 10. The team had a season-high 407 yards of offense the last time they played the Rams in Week 5.
49ers QB depth chart
Brock Purdy (questionable)
Mac Jones
Adrian Martinez
Kurtis Rourke (non-football injury list)
Jones was on the team’s injury report once again with a knee injury but was a full participant all week. Martinez may be inactive depending on Purdy’s status for the Week 10 game. If Purdy ends up unable to play, Martinez will be the backup for Jones against Los Angeles.